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ABSTRACT
| Resistance Pattern of Pseudomonas aeruginosa from Patients with Urinary Tract Infection Attending Urology/Nephrology Clinic of Usmanu Danfodiyo University Teaching Hospital, Sokoto |
| Abubakar Jibril¹, Muhammad SZ²,³, Usman MK¹, Jimoh AK⁴, Muhammad KD³, Kellu BA⁵, Emmanuel Y⁶, Yusuf AA⁷, Mohammed Y |
| Background: Pseudomonas aeruginosa is among the most common organisms implicated in causing Healthcare associated infection. It is intrinsically resistant to many antimicrobial agents and can develop resistance even during treatment both of which compromise treatment of infection caused by this agent. Aim: To isolate Pseudomonas aeruginosa and ascertain its resistance pattern from the urine of patient attending Urology/Nephrology clinic in Usmanu Danfodiyo University Teaching Hospital, Sokoto. Methodology: The study was a hospital based cross-sectional study targeting Gram negative rods from patients with urinary tract infection. The urine was collected and cultured on Cystein Lactose Electrolyte Deficient (CLED) and blood agar. All non-lactose fermenters on CLED were subjected to biochemicals (oxidase test, motility, Triple sugar iron agar, urea, citrate and pigment production on Mueller Hinton Agar) for identification. The confirmed Pseudomonas aeruginosa is further subjected to antimicrobial susceptibility testing using modified Kirby-Bauer according to Clinical and Laboratory Standard Institute (2023) guidelines. Results: The prevalence of Pseudomonas aeruginosa from clinical isolates was found to be 8.5%. Amikacin and Meropenem appeared to be the most sensitive antibiotics 29.4% each and highest level of resistance was seen in Ceftazidime and Levofloxacin 70.6% each. Ciprofloxacin had 58.8%, Cefepime, Piperacillin-tazobactam and Gentamicin had 52.9% and imipenem 35.3%. Multidrug resistant (MDR), extensively drug resistant (XDR) and Pan drug resistant (PDR) organisms made up 33.3%, 23.8% and 9.5% respectively. |
| 10.51658/ABMS.202441.10 |
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