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ISSN
2782-7550 (Print)
2782-7542 (Online)
ABSTRACT
| Protective Effects of Aqueous Syzygium aromaticum Extract on Mercury Chloride-Induced Liver Damage in Adult Wistar Rats. |
| Endurance O. Imafidon* and Atofarati O. Ayomide |
| Background: Mercury, a pervasive environmental contaminant, poses significant health risks due to its toxic effects on various organs, particularly the liver. Syzygium aromaticum has been employed for centuries as a food preservative and medicine because of its antimicrobial and antioxidant properties. This study aimed to investigate the effects of aqueous Syzygium aromaticum extract on mercury chloride-induced liver damage in adult Wistar rats. Materials and Methods: Thirty-six adult Wistar rats were randomly divided into six groups of six rats each. Group A served as the control; Group B received mercury chloride (4 mg/kg); Group C received Syzygium aromaticum extract (250 mg/kg); Group D received Syzygium aromaticum extract (500 mg/kg); Group E received Syzygium aromaticum extract (250 mg/kg) and mercury chloride (4mg/kg); Group F received Syzygium aromaticum extract (500 mg/kg) and mercury chloride (4mg/kg). At the end of the administration, the animals were sacrificed under chloroform anaesthesia. Blood sample was taken for serum alanine aminotransaminase, alkaline phosphatase, aspartate aminotransferase, and total bilirubin assessment, while tissue sample was taken for heamatoxylin and eosin histological assessments. Results: There was a significant decrease (p<0.05) in body weight as well as a significant increase (p<0.05) in liver enzymes in rats treated with mercury chloride only when compared to control. However, on pre-treatment with clove, there was a significant increase (p<0.05) in body weight and a significant decrease (p<0.05) in liver enzymes. Histological assessment showed that mercury chloride caused liver damage as characterized by necrosis, inflammation, and impaired blood flow. However, on pre-treatment with clove, there was significant improvement in the liver, characterized by relatively normal histology. Conclusion: Aqueous Syzygium aromaticum extract possesses protective properties against mercury chloride-induced hepatotoxicity in Wistar rats. |
| 10.51658/ABMS.202441.6 |
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